Formidable imaging technology shows minute structures of photoreceptors at back of eye
Denver, Colo.—Latest technological advances have begun to show unseen retinal bands answering decade old questions. A study presented this week at the 2022 Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting in Denver, Colo. used visible light Optical Coherence Tomography (OCT) to investigate outer retinal band 2. They revealed that what was originally thought to be a single entity ended up being split.
Lead researcher Vivek Srinivasan, PhD and a team consisting of researchers from NYU Langone Health and the University of California Davis used a spectral/Fourier domain visible light OCT with 1 micron axial resolution and performed it “from the fovea to the periphery” in subjects without eye disease.
As mentioned, visible light OCT revealed that band 2 is split, into bands 2a and 2b. The “topography and transverse intensity variations of the outermost band 2b” suggested to them an association with rods. This might indicate that band 2b may relate to the rod inner/outer segment junction (IS/OS). The researchers also discovered a division in the inner segments above band 2, suggestive of the boundary between the myoid and the ellipsoid.
Srinivasan said, “We imaged the living human retina with a depth resolution of one-millionth-of-a-meter. We showed extraordinarily fine details of the light sensing cells at the back of the eye for the first time, potentially allowing us to distinguish very early and subtle changes in degenerative eye diseases and guide improved treatment strategies.”
- Abstract title: Investigation of band 2 in the human outer retina with visible light Optical Coherence Tomography (OCT)
- Presentation start/end time: Wednesday, May 4, 10:17am – 10:34pm MT
- Location: 702/704/706 (Denver Convention Center)
- Also available on the virtual meeting site at https://arvo2022.arvo.org/ starting on May 11
- Abstract Number: 3511
The Association for Research in Vision and Ophthalmology (ARVO) is the largest eye and vision research organization in the world. Members include approximately 10,000 eye and vision researchers from over 75 countries. ARVO advances research worldwide into understanding the visual system and preventing, treating and curing its disorders. Learn more at ARVO.org.
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