Sunday, May 3, 8 - 10amLecture

Crossroads between the nervous and immune systems in ocular development, health and disease
Organizers: Daniel Saban and Andrew Dick
Speakers: John Forrester, Fu Shin Yu, Daniel Saban, Monica Vetter, Soyon Hong and Francisco Quintana

The inextricable link between the nervous and immune systems has been appreciated since antiquity. From the first century text, De Medicina, where Celsus described the pain as a cardinal sign of inflammation, there have since been many discoveries of how neurons modulate immunity and vice versa. This symposium wishes to further unravel the enigmatic underpinning mechanisms and facilitate discussion of the neuro-immune axis in the context of the eye. Presentations will cover neuro-inflammatory settings in the brain during immune homeostasis, dementia and inflammatory disorders to accelerate our current understanding of ocular pathobiology, including optic nerve and retina, where anatomic and cellular homologies between the brain and eye exist, as well as peripheral neuro-immune axis in the eye such as the cornea. The symposium will pave the way for exciting discussions, new opportunities, and challenges for fundamental and translational eye research.

Personalized science: Understanding human ocular disease using stem cell models
Organizers:  Stephen Russell and Mineo Kondo
Speakers:  Budd Tucker, Masayo Takahashi, Jason Meyer, Jeffrey Goldberg,  Michael Cheetham and Shukti Chakravarti

Rapid advances in stem cell technology, especially induced-pluripotent stem (iPS) cell generation and culture, have spawned a wide array of potential applications to human disease.  In addition to attempts at direct tissue replacement, the utilization of diseased, human-derived iPS cells unlocks the capacity to understand cell-level hypotheses related to genetic phenotype-genotype relationships, mechanisms of disease, and drug effects even for rare, orphan or individual family-specific diseases.  This symposium will survey these approaches applied to anterior and posterior ocular tissue targets. 

Thursday, May 7,  8 - 10amTeaching

Epigenomics and personalized medicine: "Across the globe"
Organizers: Goldis Malek and James M. Fadool
Speakers: Jayakrishna Ambati, Tara Moore, Ales Cvekl, Renu Kowluru, Michael Dyer and Louise Porter

Epigenomics and investigating accumulation of epigenetic modifications are emerging fields of study in ophthalmology, information from which has the potential to help guide individualized prevention and treatment strategies for various ocular diseases. In the spirit of the ARVO 2020 theme “Sight Saving Therapeutics”, this symposium will bring together leading scientists who will share their latest research on the role epigenomics is playing not only during development but also in shaping future personalized medicine for ocular diseases involving tissues from the anterior and posterior segments, including corneal dystrophies, glaucoma, diabetic retinopathy, and macular degeneration.

Clinical applications of artificial intelligence in the eye
Organizers: Ursula Schmidt-Erfurth, Bianca S. Gerendas 
Speakers: Michael Abramoff, Kaushal Solanki, Ursula Schmidt-Erfurth, Bianca S. Gerendas, Rhail Garnavi and Aaron Lee

This symposium will cover the advances of artificial intelligence (AI) in medicine, including machine learning and deep learning methods for clinical applications. The symposium shall discuss the future potential of both scientific developments as well as marketed products that have been approved for clinical use and their evaluation in clinical practice.